2-Chlorodeoxyadenosine Treatment in the Sezary Syndrome
نویسندگان
چکیده
منابع مشابه
2-Chlorodeoxyadenosine in the treatment of multiple myeloma.
3 4 3 encouraging results, we administered this agent to 10 patients with multiple myeloma staged according to standard criteria6; their clinical features are shown in Table 1. 2CdA was administered at a dose of 0.1 mg/kg/d for 7 days as a continuous infusion via a central venous catheter. Courses were repeated every 4 weeks. One patient received three courses, seven patients received two cours...
متن کاملTreatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA).
We administered one course of 2-chlorodeoxyadenosine (2CdA) at 4 mg/m2 daily for 7 days by continuous intravenous infusion to 46 patients with hairy cell leukemia. Complete remissions occurred in 36 patients (78%; 95% confidence limits, 63% to 89%), partial remissions in five (11%), and a minor response in one. One patient died of candida sepsis 3 weeks after beginning treatment and three patie...
متن کاملMycosis fungoides and Sezary syndrome.
YCOSIS FUNGOIDES (MF) is an uncommon, indoM lent T-cell lymphoma first described by Alibert' in the early 1800s. It primarily involves the skin at early stages of the disease, with plaques being the typical feature. After a variable period of time, it may progress with development of cutaneous tumors and spread to visceral sites and lymph nodes (LNs).* SBzary syndrome (SS) is an erythrodermic v...
متن کامل2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma
The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA) acts in non-Hodgkin's lymphoma and has been used in our center for the treatment of advanced pr...
متن کاملDiagnostics in mycosis fungoides and Sezary syndrome.
AIM The aim of this paper was to present diagnostic methods helping in the recognition of mycosis fungoides (MF) and Sezary syndrome (SS). BACKGROUND Mycosis fungoides is the most common form of primary cutaneous T-cell lymphomas. It is characterized by a distinctive long-term course and malignant T-cell proliferation. MF diagnosis is not easy, mainly due to the atypical clinical presentation...
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ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v89.4.1462